LDN-193189 (DM3189) is a selective BMP signaling inhibitor that inhibits ALK1, ALK2, ALK3, and ALK6 with IC50 of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM in kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of BMP type I receptors ALK2 and ALK3, with IC50 of 5 nM and 30 nM, respectively, in C2C12 cells, and its action on BMP is 200 times more selective than that for TGF-β. For animal testing, it is recommended to choose the water-soluble product S7507 LDN-193189 2HCl. The solubility of this product is not good, animal experiments can be used, cell experiments please choose carefully!

 

Brand: BCM

 

Target: ALK; TGF-beta/Smad

 

Signaling Pathways: Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors

 

pKa: 8.79±0.10(Predicted)

 

Solubility: Soluble in 0.01M HCl. Insoluble in DMSO; soluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3  

 

InChIKey: CDOVNWNANFFLFJ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 

 

Attribute
[Chem Name]	4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
[Synonym]	LDN-193189; DM3189
[CAS No.]	1062368-24-4
[MDL No.]	MFCD17169988
[Formula]	C25H22N6
[Molecular]	406.48
[Form]	Yellow to orange powder
[Storage]	Keep in dark place. Inert atmosphere. Room temperature

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