RCM-1 is a non-toxic inhibitor of Forkhead box M1 (FOXM1) that inhibits goblet cell metaplasia and blocks IL-13 and STAT6 signaling in mice exposed to the allergen. RCM-1 can reduce carcinogenesis and nuclear β-catenin.

 

Brand: BCM

 

In Vitro: RCM-1 inhibits cellular proliferation via the increasing duration of cell cycle and mitosis in human and mouse cancer cell lines in vitro. RCM-1 inhibits colony formation of cancer cells in vitro in a dose-dependent manner. RCM-1 inhibits the migration of cancer cells in vitro in a dose-dependent manner. RCM-1 inhibits the initiation as well as the growth of cancer cell colonies in vitro. Treatment with RCM-1 increases the duration of mitosis and cell cycle in the cancer cell lines.

 

Boiling Point: 632.8±55.0 °C(Predicted)

 

pKa: -1.42±0.37(Predicted)

 

Soluility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C1=CSC(=C1)C2=CC(=NC(=C2C#N)SCC(=O)C3=CC=CS3)C4=CC=CS4  

 

InChIKey: DCCYTKKDAZEVLY-UHFFFAOYSA-N  

 

InChI: InChI=1S/C20H12N2OS4/c21-11-14-13(17-4-1-7-24-17)10-15(18-5-2-8-25-18)22-20(14)27-12-16(23)19-6-3-9-26-19/h1-10H,12H2

 

Attribute
[Chem Name]	2-(2-oxo-2-thiophen-2-ylethyl)sulfanyl-4,6-dithiophen-2-ylpyridine-3-carbonitrile
[Synonym]	RCM-1; RCM 1; RCM1; Robert Costa Memorial drug-1
[CAS No.]	339163-65-4
[MDL No.]	MFCD00742440
[Formula]	C20H12N2OS4
[Molecular]	424.58
[Form]	Solid powder
[Storage]	Keep in dark place. Inert atmosphere. Room temperature

Goods Tag