BAY 11-7085 (Bay 11-7083) is an irreversible inhibitor of TNF-induced phosphorylation of IκBα with an IC50 of 10 μM.

 

Brand: BCM

 

Target: NF-κB; IκB/IKK; Ferroptosis; Apoptosis

 

Signaling Pathways: Apoptosis; Cell Cycle/Checkpoint; NF-κB

 

In Vitro: BAY11-7085 inhibited the expression of TNF-α-induced adhesion molecules E-selectin, VCAM-1, and ICAM-1 by inhibiting NF-κB, with no detectable cytotoxicity in HUVEC cells at 10 μM. BAY 11-7085 enhances inhibition of NFkappaB activity by paclitaxel and decreases the viability of paclitaxel-treated cells. In addition, the combination of Bay11-7085 and LY294002 had a synergistic effect on apoptosis of PEL cells.

 

Boiling Point: 407.1±45.0 °C at 760 mmHg

 

Melting Point: 80-82℃

 

Flash Point: 200.0±28.7 °C

 

Sensitivity: Light Sensitive

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)/C=C/C#N  

 

InChIKey: VHKZGNPOHPFPER-ONNFQVAWSA-N  

 

InChI: InChI=1S/C13H15NO2S/c1-13(2,3)11-5-7-12(8-6-11)17(15,16)10-4-9-14/h4-8,10H,1-3H3/b10-4+

 

Attribute
[Chem Name]	(E)-3-(4-tert-butylphenyl)sulfonylprop-2-enenitrile
[Synonym]	Bay 11-7085; BAY 11-7085
[CAS No.]	196309-76-9
[MDL No.]	MFCD01862602
[Formula]	C13H15NO2S
[Molecular]	249.33
[Form]	White to off-white solid powder
[Storage]	Sealed in dry. Room Temperature

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