4EGI-1 is a competitive inhibitor of eIF4E/eIF4G interaction by binding to eIF4E with KD value of 25 μM. 4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1. 4EGI-1 can induce apoptosis.

 

Brand: BCM

 

Target: PERK; Autophagy; Apoptosis

 

Signaling Pathways: Apoptosis; Autophagy

 

In Vitro: 4EGI-1 disrupts the eIF4F complex and inhibits CAP-mediated translation in vitro. 4EGI-1 has pro-apoptotic activity in Jurkat cells, and can effectively inhibit cell growth in A549 lung cancer cells with IC50 value of about 6μM. In human lung cancer cells, 4EGI-1 increases TRAIL-induced apoptosis by inducing DR5 and down-regulating c-FLIP, cap-dependent protein translation alone. Furthermore, in chronic lymphocytic carcinoma, 4EGI-1 restores sensitivity to ABT-737 through both CAP-dependent and non-dependent mechanisms.

 

Boiling Point: 712.2±70.0 °C at 760 mmHg

 

Flash Point: 384.5±35.7 °C

 

Vapour Pressure: 0.0±2.4 mmHg at 25°C

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C1=CC=C(C(=C1)C/C(=N\NC2=NC(=CS2)C3=CC(=C(C=C3)Cl)Cl)/C(=O)O)[N+](=O)[O-]  

 

InChIKey: KFRKRECSIYXARE-HYARGMPZSA-N  

 

InChI: InChI=1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14+

 

Attribute
[Chem Name]	(2E)-2-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]-3-(2-nitrophenyl)propanoic acid
[Synonym]	4EGI-1
[CAS No.]	315706-13-9
[EINECS]	2017-001-1
[MDL No.]	MFCD28142689
[Formula]	C18H12Cl2N4O4S
[Molecular]	451.28
[Form]	Brown solid
[Storage]	Sealed in dry. Store in freezer, under -20°C

Goods Tag