Verteporfin is a small molecule compound capable of inhibiting the YAP-TEAD interaction and inhibiting YAP-induced liver overgrowth. It is also an effective second generation photosensitizer derived from porphyrins. Verteporfin is an autophagy inhibitor. Verteporfin can inhibit cell proliferation and induce apoptosis.

 

Brand: BCM

 

Target: YAP; Apoptosis; Autophagy; VDA

 

Signaling Pathways: Angiogenesis; Apoptosis; Autophagy; Stem Cells

 

In Vivo: Verteporfin can be used for vascular visualization of choroidal blood vessels and CNVS, demonstrating rapid aggregation of photosensitizers in experimental CNVS in monkeys. Verteporfin rapidly accumulates in the established choroidal vasculature, RPE, and photoreceptors of the rabbit eye. In mice, Verteporfin reached maximum tissue levels 3 hours after intravenous administration, followed by a rapid decline within 24 hours. Verteporfin is metabolized to a less active form in the body and is quickly cleared, mostly by excretion in the stool and a small percentage in urine. The effective selectivity of the Verteporfin therapy prevented the leakage of fluorescent dye from experimentally induced monkey CNV.

 

Sensitivity: Sensitive to light.

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

Isomeric SMILES: CC1=C(C2=CC3=NC(=CC4=C(C(=C(N4)C=C5[C@@]6([C@@H](C(=CC=C6C(=N5)C=C1N2)C(=O)OC)C(=O)OC)C)C)CCC(=O)OC)C(=C3C)CCC(=O)O)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C(N4)C=C5[C@@]6([C@@H](C(=CC=C6C(=N5)C=C1N2)C(=O)OC)C(=O)OC)C)C)CCC(=O)O)C(=C3C)CCC(=O)OC)C=C  

 

InChIKey: NJLRKAMQPVVOIU-IDLGWYNRSA-N  

 

InChI: InChI=1S/2C41H42N4O8/c1-9-23-20(2)29-17-34-27-13-10-26(39(49)52-7)38(40(50)53-8)41(27,5)35(45-34)19-30-22(4)24(11-14-36(46)47)32(44-30)18-33-25(12-15-37(48)51-6)21(3)28(43-33)16-31(23)42-29;1-9-23-20(2)29-17-34-27-13-10-26(39(49)52-7)38(40(50)53-8)41(27,5)35(45-34)19-30-22(4)25(12-15-37(48)51-6)33(44-30)18-32-24(11-14-36(46)47)21(3)28(43-32)16-31(23)42-29/h2*9-10,13,16-19,38,42,44H,1,11-12,14-15H2,2-8H3,(H,46,47)/t2*38-,41+/m00/s1

 

Attribute
[Chem Name]	3-[(23S,24R)-14-ethenyl-22,23-bis(methoxycarbonyl)-5-(3-methoxy-3-oxopropyl)-4,10,15,24-tetramethyl-25,26,27,28-tetrazahexacyclo[16.6.1.13,6.18,11.113,16.019,24]octacosa-1,3,5,7,9,11(27),12,14,16,18(25),19,21-dodecaen-9-yl]propanoic acid;3-[(23S,24R)-14-ethenyl-22,23-bis(methoxycarbonyl)-9-(3-methoxy-3-oxopropyl)-4,10,15,24-tetramethyl-25,26,27,28-tetrazahexacyclo[16.6.1.13,6.18,11.113,16.019,24]octacosa-1,3,5,7,9,11(27),12,14,16,18(25),19,21-dodecaen-5-yl]propanoic acid
[Synonym]	Verteporfin; CL 318952
[CAS No.]	129497-78-5
[MDL No.]	MFCD11982858
[Formula]	2C41H42N4O8
[Molecular]	1437.61
[Form]	Black Powder
[Storage]	Keep in dark place. Inert atmosphere. Store in freezer, under -20°C

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