EX229 is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.

 

Brand: BCM

 

Target: AMPK

 

Signaling Pathways: Chromatin/Epigenetic; PI3K/Akt/mTOR signaling

 

Boiling Point: 706.4±70.0 °C(Predicted)

 

pKa: 3.40±0.25(Predicted)

 

Solubility: Soluble in DMSo. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: CC1=C(C=C(C=C1)OC2=NC3=C(N2)C=C(C(=C3)C4=CC5=C(C=C4)N(C=C5)C)Cl)C(=O)O  

 

InChIKey: FHWSAZXFPUMKFL-UHFFFAOYSA-N  

 

InChI: InChI=1S/C24H18ClN3O3/c1-13-3-5-16(10-17(13)23(29)30)31-24-26-20-11-18(19(25)12-21(20)27-24)14-4-6-22-15(9-14)7-8-28(22)2/h3-12H,1-2H3,(H,26,27)(H,29,30)

 

Attribute
[Chem Name]	5-[[6-chloro-5-(1-methylindol-5-yl)-1H-benzimidazol-2-yl]oxy]-2-methylbenzoic acid
[Synonym]	EX229; ex229; AMPK Activator 991; compound 991
[CAS No.]	1219739-36-2
[MDL No.]	MFCD31696597
[Formula]	C24H18ClN3O3
[Molecular]	431.87
[Form]	Solid Powder
[Storage]	Sealed in dry, 2-8°C

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