ASP2453 is a potent, selective, and covalent KRAS G12C inhibitor that inhibits the Son of Sevenless (SOS) -mediated interaction between KRAS G12C and Raf and is a potential therapeutic agent for KRAS G12C-mutated cancers.

 

Brand: BCM

 

Target: Ras

 

Signaling Pathways: GPCR/G Protein; MAPK

 

Boiling Point: 855.8±75.0 °C(Predicted)

 

pKa: 12.36±0.40(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC1=C(C2=C(C=C1)NN=C2)C3=C(C=C4C(=C3OCC(F)(F)F)N=C(N=C4N5CCC6(CC5)CN(C6)C(=O)C=C)OC7CCN(CC7)CCCOC)C8CC8  

 

InChIKey: VEXDXXFHISGELS-UHFFFAOYSA-N  

 

InChI: InChI=1S/C40H48F3N7O4/c1-4-32(51)50-22-39(23-50)12-17-49(18-13-39)37-29-20-28(26-7-8-26)34(33-25(2)6-9-31-30(33)21-44-47-31)36(53-24-40(41,42)43)35(29)45-38(46-37)54-27-10-15-48(16-11-27)14-5-19-52-3/h4,6,9,20-21,26-27H,1,5,7-8,10-19,22-24H2,2-3H3,(H,44,47)

 

Attribute
[Chem Name]	1-[7-[6-cyclopropyl-2-[1-(3-methoxypropyl)piperidin-4-yl]oxy-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)quinazolin-4-yl]-2,7-diazaspiro[3.5]nonan-2-yl]prop-2-en-1-one
[Synonym]	ASP2453
[CAS No.]	2241719-73-1
[Formula]	C40H48F3N7O4
[Molecular]	747.85
[Form]	Solid Powder
[Storage]	Seaked in dry. Stored at -20°C

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