PF-9366 is a human methionine adenosyltransferase 2A (MAT2A) inhibitor with IC50 of 420 nM and Kd of 170 nM.

 

Brand: BCM

 

Target: Others; Methionine Adenosyltransferase (MAT)

 

Signaling Pathways: Chromatin/Epigenetic; Others

 

Melting Point: 182-183.5 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))

 

pKa: 8.75±0.28(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CN(C)CCC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=C2)C4=CC=CC=C4  

 

InChIKey: LYLASWLQCMKZAT-UHFFFAOYSA-N  

 

InChI: InChI=1S/C20H19ClN4/c1-24(2)11-10-19-22-23-20-13-16(14-6-4-3-5-7-14)17-12-15(21)8-9-18(17)25(19)20/h3-9,12-13H,10-11H2,1-2H3 

 

Attribute
[Chem Name]	2-(7-chloro-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethanamine
[Synonym]	PF-9366
[CAS No.]	72882-78-1
[MDL No.]	MFCD31630724
[Formula]	C20H19ClN4
[Molecular]	350.84
[Form]	Beige solid powder
[Storage]	Sealed in dry, 2-8°C

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