Entinostat (MS-275, SNDX-275) strongly inhibited HDAC1 and HDAC3, with IC50 of 0.51 μM and 1.7 μM, respectively, in cell-free tests, which was stronger than HDACs 4, 6, 8, and 10. Entinostat can induce autophagy and apoptosis. Phase 3.

 

Brand: BCM

 

Target: Apoptosis; Autophagy; HDAC

 

Signaling Pathways: Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair

 

Melting Point: 159-160 ºC

 

Boiling Point: 566.7±50.0 °C(Predicted)

 

pKa: 11.32±0.46(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS06, GHS08

 

Isomeric SMILES: C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3  

 

InChIKey: INVTYAOGFAGBOE-UHFFFAOYSA-N  

 

InChI: InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26) 

 

Attribute
[Chem Name]	pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate
[Synonym]	Entinostat; SNDX-275; MS-275
[CAS No.]	209783-80-2
[MDL No.]	MFCD08272435
[Formula]	C21H20N4O3
[Molecular]	376.41
[Form]	Pale yellow solid
[Storage]	Keep in dark place. Sealed in dry. Store in freezer, under -20°C

Goods Tag