KP-457 (TNF-alpha-converting enzyme) is a selective inhibitor of ADAM17 with an IC50 of 11.1 nM/L (cell-free assay). It can also cut various molecules, such as GPIbα, GPV, and TNF-α.

 

Brand: BCM

 

Boiling Point: 747.5±70.0 °C(Predicted)

 

pKa: 7.57±0.69(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: CC#CCOC1=CC=C(C=C1)S(=O)(=O)CC(C2=CC=C(C=C2)CNS(=O)(=O)C)N(C=O)O  

 

InChIKey: VIWDSTUVCAZZDF-UHFFFAOYSA-N  

 

InChI: InChI=1S/C21H24N2O7S2/c1-3-4-13-30-19-9-11-20(12-10-19)32(28,29)15-21(23(25)16-24)18-7-5-17(6-8-18)14-22-31(2,26)27/h5-12,16,21-22,25H,13-15H2,1-2H3

 

Attribute
[Chem Name]	N-[2-(4-but-2-ynoxyphenyl)sulfonyl-1-[4-(methanesulfonamidomethyl)phenyl]ethyl]-N-hydroxyformamide
[Synonym]	KP-457; TNF‐α‐converting enzyme
[CAS No.]	1365803-52-6
[EINECS]	828-030-7
[Formula]	C21H24N2O7S2
[Molecular]	480.55
[Form]	Solid Powder
[Storage]	Stored at -20°C

Goods Tag