KSQ-4279 (USP1-in-1) is an oral bioavailable selective inhibitor of ubiquitin specific protease 1 (USP1) with anti-proliferative activity. KSQ-4279 also showed synergistic activity when used in combination with PARP inhibitors.

 

Brand: BCM

 

Target: PARP; DUB

 

Signaling Pathways: Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Ubiquitination

 

pKa: 2.85±0.60(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC(C)N1C=C(N=C1C2=CC=C(C=C2)CN3C4=NC(=NC=C4C=N3)C5=C(N=CN=C5OC)C6CC6)C(F)(F)F  

 

InChIKey: KCBWAFJCKVKYHO-UHFFFAOYSA-N  

 

InChI: InChI=1S/C27H25F3N8O/c1-15(2)37-13-20(27(28,29)30)35-24(37)18-6-4-16(5-7-18)12-38-25-19(11-34-38)10-31-23(36-25)21-22(17-8-9-17)32-14-33-26(21)39-3/h4-7,10-11,13-15,17H,8-9,12H2,1-3H3

 

Attribute
[Chem Name]	6-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-1-[[4-[1-propan-2-yl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine
[Synonym]	KSQ-4279； USP1-IN-1
[CAS No.]	2446480-97-1
[Formula]	C27H25F3N8O
[Molecular]	534.54
[Form]	Solid Powder
[Storage]	Sealed in dry, 2-8°C

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