Safimaltib(JNJ-67856633,JNJ-6633) is a potent and selective allosteric inhibitor of MALT1 protease.

 

Brand: BCM

 

Target: MALT

Signaling Pathways: Immunology/Inflammation

 

In Vitro: JNJ-67856633 is effective and highly bioavailable in both mouse and rat tumors, and in some cases led to tumor stasis. JNJ-67856633 results in potent in vivo pharmacodynamic shutdown in CD79b- as well as CARD11-mutant ABC-DLBCL models as measured by serum IL10 or uncleaved BCL10 levels in tumors.

 

Boiling Point: 570.0±50.0 °C(Predicted)

 

pKa: 11.01±0.70(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: C1=CC2=C(C=CNC2=O)C(=C1)N3C(=C(C=N3)C(=O)NC4=CC(=NC=C4)C(F)(F)F)C(F)(F)F  

 

InChIKey: APWRZPQBPCAXFP-UHFFFAOYSA-N  

 

InChI: InChI=1S/C20H11F6N5O2/c21-19(22,23)15-8-10(4-6-27-15)30-18(33)13-9-29-31(16(13)20(24,25)26)14-3-1-2-12-11(14)5-7-28-17(12)32/h1-9H,(H,28,32)(H,27,30,33) 

 

Attribute
[Chem Name]	1-(1-oxo-2H-isoquinolin-5-yl)-5-(trifluoromethyl)-N-[2-(trifluoromethyl)pyridin-4-yl]pyrazole-4-carboxamide
[Synonym]	Safimaltib; JNJ-67856633; JNJ-6633
[CAS No.]	2230273-76-2
[MDL No.]	MFCD34475932
[Formula]	C20H11F6N5O2
[Molecular]	467.32
[Form]	Solid Powder
[Storage]	Sealed in dry. Stored at -20°C.

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