Mycro 3 is a potent and selective c-Myc inhibitor in whole cell trials. Mycro 3 also showed weak inhibitory activity against AP-1.

 

Brand: BCM

 

Target: c-Myc; Autophagy

 

Signaling Pathways: Autophagy; Cell Cycle/Checkpoint

 

In Vitro: Mycro 3 inhibits the interaction between c-Myc and Max. Mycro 3 has high selectivity and inhibits c-Myc/Max dimerization and conjugation with DNA. Mycro 3 is potent and selective for c-Myc in whole cell assays, with weak inhibitory activity against Activator protein 1 (AP-1), Mycro 3 has a superior specificity profile to its predecessors.

 

pKa: 6.95±0.46(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: CCOC(=O)C1=C(N(N=C1)C2=CC=CC=C2)NC(=O)C3=NN4C(=CC(=NC4=C3)C5=CC=CO5)C(F)(F)Cl  

 

InChIKey: YPPNLSKYXDXQGD-UHFFFAOYSA-N  

 

InChI: InChI=1S/C24H17ClF2N6O4/c1-2-36-23(35)15-13-28-32(14-7-4-3-5-8-14)21(15)30-22(34)17-12-20-29-16(18-9-6-10-37-18)11-19(24(25,26)27)33(20)31-17/h3-13H,2H2,1H3,(H,30,34)

 

Attribute
[Chem Name]	ethyl 5-[[7-[chloro(difluoro)methyl]-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]-1-phenylpyrazole-4-carboxylate
[Synonym]	Mycro 3; Mycro3; Mycro-3
[CAS No.]	944547-46-0
[MDL No.]	MFCD03409284
[Formula]	C24H17ClF2N6O4
[Molecular]	526.88
[Form]	Solid Powder
[Storage]	Sealed in dry. Store in freezer, under -20°C

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