THAL-SNS-032 is a selective Cyclin-dependent kinase 9 (CDK9) degradant PROTAC. Contains a CDK-binding SNS-032 ligand, a thalidomide derivative, and E3 ubiquitin ligase Cereblon (CRBN).

 

Brand: BCM

 

Target: CDK

 

Signaling Pathways: Cell Cycle/Checkpoint

 

pKa: 7.86±0.70(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCN(CC3)CC(=O)NCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O  

 

InChIKey: BXDZOYLPNAIDOC-UHFFFAOYSA-N  

 

InChI: InChI=1S/C40H52N8O10S2/c1-40(2,3)29-21-43-32(58-29)24-59-33-22-44-39(60-33)46-35(51)25-9-13-47(14-10-25)23-31(50)42-12-16-56-18-20-57-19-17-55-15-11-41-27-6-4-5-26-34(27)38(54)48(37(26)53)28-7-8-30(49)45-36(28)52/h4-6,21-22,25,28,41H,7-20,23-24H2,1-3H3,(H,42,50)(H,44,46,51)(H,45,49,52)

 

Attribute
[Chem Name]	N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]-1-[2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]piperidine-4-carboxamide
[Synonym]	THAL-SNS-032
[CAS No.]	2139287-33-3
[MDL No.]	MFCD31689257
[Formula]	C40H52N8O10S2
[Molecular]	869.02
[Form]	Solid Powder
[Storage]	Inert atmosphere. Store in freezer, under -20°C

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