SR9011 is a REV-ERBα/β agonist with an IC50 of 790 nM for REV-ERBα and 560 nM for REV-ERBβ. It has specific lethal effects on cancer cells and oncogene-induced senescent cells, including melanocyte nevus.

 

Brand: BCM

 

Target: Autophagy

 

Signaling Pathways: Autophagy

 

In Vitro: SR9011 and SR9009 effectively inhibits transcription in a cotransfection assay using full-length REV-ERBα along with a luciferase reporter driven by the Bmal1 promoter (SR9011 IC50: 620 nM). SR9011 suppresses the expression of BMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner.

 

Boiling Point: 642.8±50.0 °C(Predicted)

 

pKa: 14.71±0.40(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

IUPAC Name: 3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]-N-pentylpyrrolidine-1-carboxamide  

 

Isomeric SMILES: CCCCCNC(=O)N1CCC(C1)CN(CC2=CC=C(C=C2)Cl)CC3=CC=C(S3)[N+](=O)[O-]  

 

InChIKey: PPUYOYQTTWJTIU-UHFFFAOYSA-N  

 

InChI: InChI=1S/C23H31ClN4O3S/c1-2-3-4-12-25-23(29)27-13-11-19(16-27)15-26(14-18-5-7-20(24)8-6-18)17-21-9-10-22(32-21)28(30)31/h5-10,19H,2-4,11-17H2,1H3,(H,25,29)

 

Attribute
[Chem Name]	3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]-N-pentylpyrrolidine-1-carboxamide
[Synonym]	SR9011
[CAS No.]	1379686-29-9
[MDL No.]	MFCD29472235
[Formula]	C23H31ClN4O3S
[Molecular]	479.04
[Form]	Solid Powder
[Storage]	Keep in dark place. Sealed in dry. Store in freezer, under -20°C

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