ONO-AE3-208(AE 3-208) is a selective oral active EP4 receptor antagonist with a Ki of 1.3 nM, which is less potent against EP3, FP, and TP receptor Ki of 30 nM, 790 nM, and 2400 nM, respectively.

 

Brand: BCM

 

Target: Prostaglandin Receptor

 

Signaling Pathways: GPCR/G Protein; Immunology/Inflammation

 

In Vitro: ONO-AE3-208 abolishes CTGF in the presence of the EET synthesis inhibitor MS-PPOH. Arachidonic acid causes the dose-dependent dilation of the attached Af-Art, and this effect is blocked by ONO-AE3-208

 

Boiling Point: 662.4±55.0 °C(Predicted)

 

pKa: 4.69±0.10(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC(C1=CC=C(C2=CC=CC=C21)F)C(=O)NC3=C(C=CC(=C3)C#N)CCCC(=O)O  

 

InChIKey: MTDIMKNAJUQTIO-UHFFFAOYSA-N  

 

InChI: InChI=1S/C24H21FN2O3/c1-15(18-11-12-21(25)20-7-3-2-6-19(18)20)24(30)27-22-13-16(14-26)9-10-17(22)5-4-8-23(28)29/h2-3,6-7,9-13,15H,4-5,8H2,1H3,(H,27,30)(H,28,29)

 

Attribute
[Chem Name]	4-[4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]butanoic acid
[Synonym]	ONO-AE3-208; AE 3-208
[CAS No.]	402473-54-5
[MDL No.]	MFCD13184814
[Formula]	C24H21FN2O3
[Molecular]	404.43
[Form]	White to beige powder
[Storage]	Sealed in dry. Store in freezer, under -20°C

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