TC-S 7009 is a potent selective HIF-2α inhibitor with a Kd value of 81 nM. TC-S 7009 is more selective to HIF-2α than HIF-1α. It disrupts HIF-2α heterodimerization, reduces DNA binding activity, and reduces HIF-2α target gene expression.

 

Brand: BCM

 

Target: HIF

 

Signaling Pathways: Angiogenesis; Chromatin/Epigenetic

 

In Vitro: TC-S 7009 (50 μM) treatment almost fully inhibits hypoxia-induced NFATc2 nuclear translocation. TC-S 7009 (0-100 µM; 72 hours; HPF cells) treatment displays greater inhibition of cell proliferation in hypoxic conditions than that in normoxic conditions

 

Boiling Point: 430.2±55.0 °C(Predicted)

 

pKa: -2.82±0.48(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

GHS: GHS06

 

Isomeric SMILES: C1=CC2=NON=C2C(=C1NC3=CC(=CC(=C3)Cl)F)[N+](=O)[O-]  

 

InChIKey: CDQUJZKBRAFWNG-UHFFFAOYSA-N  

 

InChI: InChI=1S/C12H6ClFN4O3/c13-6-3-7(14)5-8(4-6)15-10-2-1-9-11(17-21-16-9)12(10)18(19)20/h1-5,15H

 

Attribute
[Chem Name]	N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
[Synonym]	TC-S 7009
[CAS No.]	1422955-31-4
[MDL No.]	MFCD25371546
[Formula]	C12H6ClFN4O3
[Molecular]	308.65
[Form]	White to beige powder
[Storage]	Sealed in dry. Stored at -20°C.

Goods Tag