DMOG (Dimethyloxalylglycine) is an antagonist of alpha-ketoglutarate cofactor and an inhibitor of HIF prolylhydroxylase, which stabilizes and accumulates HIF-1α protein in the nucleus and acts as an agonist for HIF-1α. DMOG can increase autophagy.

 

Brand: BCM

 

Target: HIF/HIF Prolyl-Hydroxylase; HIF; Autophagy

Signaling Pathways: Angiogenesis; Autophagy; Chromatin/Epigenetic; Metabolism

 

In Vitro: DMOG shows only weakly active in the microsomal system, but efficiently suppresses hydroxyproline synthesis in intact cells. DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC. 

 

Melting Point: 46-48°C

 

Boiling Point: 179-182 °C(Press: 12 Torr)

 

pKa: 10.55±0.46(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Water; Solule in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: COC(=O)CNC(=O)C(=O)OC  

 

InChIKey: BNJOZDZCRHCODO-UHFFFAOYSA-N  

 

InChI: InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)

 

Attribute
[Chem Name]	methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetate
[Synonym]	DMOG; Dimethyloxalylglycine
[CAS No.]	89464-63-1
[EINECS]	200-256-5
[MDL No.]	MFCD05865098
[Formula]	C6H9NO5
[Molecular]	175.14
[Form]	White to off-white powder
[Storage]	Sealed in dry. Store in freezer, under -20°C

Goods Tag