7BIO, a derivative of indirubin, inhibits cyclin-dependent kinase 5 and glycogen synthase kinase-3β. It inhibits Aβ oligomer-induced neuroinflammation, synaptic damage, tau hyperphosphorylation, astrocyte and microglial activation, and alleviates Aβ oligomer-induced cognitive impairment in mice.

 

Brand: BCM

 

Target: FLT; DYRK; Aurora Kinase

 

Signaling Pathways: Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

Isomeric SMILES: C1=CC=C2C(=C1)C(=C(N2)C3=C(NC4=C3C=CC=C4Br)O)N=O  

 

InChIKey: HYMACPDEJIEMST-UHFFFAOYSA-N  

 

InChI: InChI=1S/C16H10BrN3O2/c17-10-6-3-5-9-12(16(21)19-13(9)10)15-14(20-22)8-4-1-2-7-11(8)18-15/h1-7,18-19,21H

 

Attribute
[Chem Name]	7-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol
[Synonym]	7BIO; 7-bromoindirubin-3-oxime
[CAS No.]	916440-85-2
[MDL No.]	MFCD28898970
[Formula]	C16H10BrN3O2
[Molecular]	356.17
[Form]	Dark red solid powder
[Storage]	Sealed in dry, 2-8°C

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