RQ00203078 is an orally effective and highly selective antagonist of TRPM8 with IC50 of 5.3 nM and 8.3 nM for rat and human TRPM8 channels, respectively. It has little inhibitory effect on TRPV1, TRPA1, TRPV4 or TRPM2 channels.

 

Brand: BCM

 

Target: TRP/TRPV Channel

 

Signaling Pathways: Membrane transporter/Ion channel

 

Boiling Point: 602.0±65.0 °C(Predicted)

 

pKa: 3.39±0.10(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: C1=CC(=CC=C1CN(C2=C(C=C(C=N2)C(F)(F)F)Cl)S(=O)(=O)C3=CC=C(C=C3)C(=O)O)OC(F)(F)F  

 

InChIKey: IJGQFZYYEHCCIZ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C21H13ClF6N2O5S/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-12-1-5-15(6-2-12)35-21(26,27)28)36(33,34)16-7-3-13(4-8-16)19(31)32/h1-10H,11H2,(H,31,32) 

 

Attribute
[Chem Name]	4-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-[[4-(trifluoromethoxy)phenyl]methyl]sulfamoyl]benzoic acid
[Synonym]	RQ-00203078
[CAS No.]	1254205-52-1
[MDL No.]	MFCD29049510
[Formula]	C21H13ClF6N2O5S
[Molecular]	554.85
[Form]	Solid
[Storage]	Inert atmosphere, 2-8°C

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