AZ20 is a novel and potent selective ATR kinase inhibitor with an IC50 of 5 nM in cell-free trials, which is 8 times more selective than for mTOR.

 

Brand: BCM

 

Target: ATM/ATR; mTOR

 

Signaling Pathways: DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling

 

In Vitro: AZ20 (10 μM) inhibited 50% of CYP3A4-mediated midazolam metabolism. In female nude mice with LoVo tumor, AZ20 (25 mg/kg, twice a day,p.o.) was administered for 13 days. 50 mg/kg/day,p.o. significantly inhibited tumor growth, which was associated with a sustained and widespread increase in γH2AX nuclear staining in xenograft tissues.

 

Boiling Point: 634.6±55.0 °C(Predicted)

 

pKa: 15.65±0.30(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: C[C@@H]1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=O)(=O)C)C4=C5C=CNC5=CC=C4  

 

InChIKey: SCGCBAAYLFTIJU-CQSZACIVSA-N  

 

InChI: InChI=1S/C21H24N4O3S/c1-14-13-28-11-10-25(14)19-12-18(21(7-8-21)29(2,26)27)23-20(24-19)16-4-3-5-17-15(16)6-9-22-17/h3-6,9,12,14,22H,7-8,10-11,13H2,1-2H3/t14-/m1/s1

 

Attribute
[Chem Name]	(3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine
[Synonym]	AZ20
[CAS No.]	1233339-22-4
[MDL No.]	MFCD25976730
[Formula]	C21H24N4O3S
[Molecular]	412.51
[Form]	Off-white solid
[Storage]	Sealed in dry, 2-8°C

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