SKLB197 can selectively inhibit mutant Ataxia telangiectasia mutated and Rad3-related (ATR) kinase with IC50 of 0.013 μM. It showed strong antitumor activity both in vivo and in vitro.

 

Brand: BCM

 

Boiling Point: 612.2±55.0 °C(Predicted)

 

pKa: 15.61±0.30(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

Isomeric SMILES: C[C@@H]1COCCN1C2=NC(=NC3=C2C=C(C=C3)C4=CC=NN4C)C5=C6C=CNC6=CC=C5  

 

InChIKey: FCNFJRRMUAOHKI-MRXNPFEDSA-N  

 

InChI: InChI=1S/C25H24N6O/c1-16-15-32-13-12-31(16)25-20-14-17(23-9-11-27-30(23)2)6-7-22(20)28-24(29-25)19-4-3-5-21-18(19)8-10-26-21/h3-11,14,16,26H,12-13,15H2,1-2H3/t16-/m1/s1

 

Attribute
[Chem Name]	(3R)-4-[2-(1H-indol-4-yl)-6-(2-methylpyrazol-3-yl)quinazolin-4-yl]-3-methylmorpholine
[Synonym]	SKLB-197
[CAS No.]	2713577-16-1
[Formula]	C25H24N6O
[Molecular]	424.5
[Form]	Solid powder
[Storage]	Sealed in dry. Stored at -20°C.

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