FH535 is a Wnt/β-catenin signaling inhibitor and a dual antagonist of PPARγ and PPARδ.

 

Brand: BCM

 

Target: Wnt/beta-catenin; PPAR

 

Signaling Pathways: Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; Stem Cells

 

In Vivo: FH535 inhibits β-catenin/TCF-mediated transcription, and also inhibits the aggregation of pPARδ and PPAR by co-activators GRIP1 and β-catenin. In cancer cells with high expression or active Wnt/ β-catenin pathways,FH535 inhibits cell proliferation.

 

Melting Point: 141-142℃

 

Boiling Point: 526.3±60.0 °C(Predicted)

 

pKa: 5.83±0.10(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

GHS: GHS05, GHS07

 

Isomeric SMILES: CC1=C(C=CC(=C1)[N+](=O)[O-])NS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl  

 

InChIKey: AXNUEXXEQGQWPA-UHFFFAOYSA-N  

 

InChI: InChI=1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3

 

Attribute
[Chem Name]	2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide
[Synonym]	FH535
[CAS No.]	108409-83-2
[MDL No.]	MFCD01212888
[Formula]	C13H10Cl2N2O4S
[Molecular]	361.2
[Form]	Yellow solid
[Storage]	Keep in dark place. Inert atmosphere. Room temperature

Goods Tag