JNJ-632 is a potent hepatitis B virus (HBV) capsid assembly modulator (CAM) assembly modulator with a mean EC50 value of 121 nM in HepG2.2.15 cells.

 

Brand: BCM

 

Target: HBV

 

Signaling Pathways: Microbiology/Virology

 

In Vivo: Administration of JNJ-632 (54) in HBV genotype D infected chimeric mice resulted in a 2.77 log reduction of the HBV DNA viral load.

 

pKa: 10.37±0.20(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: CC1=C(C=CC(=C1)NC(=O)C2=CC(=CC=C2)S(=O)(=O)N[C@H]3CCOC3)F  

 

InChIKey: JIZGLOVJKCSHTH-HNNXBMFYSA-N  

 

InChI: InChI=1S/C18H19FN2O4S/c1-12-9-14(5-6-17(12)19)20-18(22)13-3-2-4-16(10-13)26(23,24)21-15-7-8-25-11-15/h2-6,9-10,15,21H,7-8,11H2,1H3,(H,20,22)/t15-/m0/s1 

 

Attribute
[Chem Name]	N-(4-fluoro-3-methylphenyl)-3-[[(3S)-oxolan-3-yl]sulfamoyl]benzamide
[Synonym]	JNJ-632; JNJ632
[CAS No.]	1572510-42-9
[MDL No.]	MFCD31692402
[Formula]	C18H19FN2O4S
[Molecular]	378.42
[Form]	A crystalline solid
[Storage]	Inert atmosphere. Room Temperature

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