Oridonin (Isodonol, Rubescenin, NSC-250682), an enantiokaurane diterpene isolated from Rabdosia rubescens, is a traditional Chinese medicine with anti-tumor, anti-bacterial and anti-infective effects. Oridonin inhibited AKT1 and AKT2 kinase activity with corresponding IC50 values of 8.4 μM and 8.9 μM, respectively.

 

Brand: BCM

 

Target: Akt; Antibacterial

 

Signaling Pathways: Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling

 

In Vitro: Oridonin effectively inhibits the proliferation of various cancer cells, including those from prostate cancer (LNCaP, DU145, PC3), breast cancer (MCF-7, MDA-MB231), non-small cell lung cancer (NSCL) (NCI-H520, NCI-H460, NCI-H1299), Cell proliferation in acute promyelocytic leukemia (NB4), as well as glioblastoma (U118, U138), ranges from 1.8 to 7.5 μg/ml for ED50s. The antitumor activity of Oridonin may be due to its inhibitory effect on NF-κB and MAPKs signaling pathways

 

Melting Point: 248-250°C

 

Boiling Point: 599.8±50.0 °C(Predicted)

 

pKa: 10.96±0.70(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: CC1(CC[C@@H]([C@]23[C@@H]1[C@@H]([C@]([C@]45[C@H]2CC[C@H]([C@H]4O)C(=C)C5=O)(OC3)O)O)O)C  

 

InChIKey: SDHTXBWLVGWJFT-XKCURVIJSA-N  

 

InChI: InChI=1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13+,15+,16-,18+,19-,20+/m0/s1

 

Attribute
[Chem Name]	(1S,2S,5S,8R,9S,10S,11R,15S,18R)-9,10,15,18-tetrahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one
[Synonym]	Oridonin; NSC-250682; Isodonol; Rubescenin
[CAS No.]	28957-04-2
[MDL No.]	MFCD00221762
[Formula]	C20H28O6
[Molecular]	364.44
[Form]	White or off-white solid
[Storage]	Sealed in dry. Room Temperature

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