Terevalefim (ANG-3777) is a small molecule hepatocyte growth factor (HGF) analog that induces c-MET dimerization and phosphorylation, reduces apoptosis and increases cell proliferation.

 

Brand: BCM

 

Target: c-Met/HGFR

 

Signaling Pathways: Tyrosine Kinase/Adaptors

 

In Vitro: Terevalefim (ANG-3777) (0-10 μM) significantly inhibited cancer cells proliferation in HUVECs.

 

Boiling Point: 369.3±11.0 °C(Predicted)

 

pKa: 14.05±0.10(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: C1=CSC(=C1)/C=C/C2=CC=NN2  

 

InChIKey: FOHWAQGURRYJFK-ONEGZZNKSA-N  

 

InChI: InChI=1S/C9H8N2S/c1-2-9(12-7-1)4-3-8-5-6-10-11-8/h1-7H,(H,10,11)/b4-3+

 

Attribute
[Chem Name]	5-[(E)-2-thiophen-2-ylethenyl]-1H-pyrazole
[Synonym]	ANG-3777; Terevalefim
[CAS No.]	1070881-42-3
[Formula]	C9H8N2S
[Molecular]	176.24
[Form]	Solid Powder
[Storage]	Sealed in dry. Stored at -20°C.

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