Nocodazole is a rapid reversible inhibitor of microtubule polymerization and also inhibits Abl, Abl(E255K), and Abl(T315I) with corresponding IC50 values of 0.21 μM, 0.53 μM, and 0.64 μM, respectively. Nocodazole improves the efficiency of CRISPR-mediated homologous recombination and has a additive effect on enhancing the effectiveness of precise gene editing. Nocodazole can induce apoptosis.

 

Brand: BCM

 

Target: Apoptosis; Microtubule Associated; Bcr-Abl; Autophagy; CRISPR/Cas9

 

Signaling Pathways: Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors

 

In Vitro: In the COLO205 tumor transplantation model,Nocodazole combined with ketoconazole enhanced apoptosis induction and significantly inhibited tumor volume and weight in mice.

 

Melting Point: 300 °C (dec.)

 

pKa: 10.67±0.10(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

GHS: GHS08

 

Isomeric SMILES: COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3  

 

InChIKey: KYRVNWMVYQXFEU-UHFFFAOYSA-N  

 

InChI: InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19) 

 

Attribute
[Chem Name]	methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate
[Synonym]	Nocodazole; R17934; Oncodazole; NSC238159
[CAS No.]	31430-18-9
[EINECS]	250-626-5
[MDL No.]	MFCD00005588
[Formula]	C14H11N3O3S
[Molecular]	301.32
[Form]	White powder
[Storage]	Sealed in dry. Store in freezer, under -20°C

Goods Tag