Chloroquine (NSC-187208, CHQ, CQ) is an antimalarial agent and an inhibitor of autophagy and lysosome. Chloroquine also inhibits the expression of Toll-like receptor-9 (TLR9) protein. Chloroquine is a highly effective anti-SARS-CoV-2 (COVID-19) infection agent with an EC50 value of 1.13 μM in Vero E6 cells. Chloroquine also has anti-HIV-1 activity.

 

Brand: BCM

 

Target:  Autophagy; lysosome; TLR9; HIV-1; SARS-CoV-2(Vero E6 cells based assay)1.13 μM(EC50)

 

Melting Point: 87°C

 

Boiling Point: 475.41°C (rough estimate)

 

pKa: 8.4(H2O t = 20) (Uncertain)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl  

 

InChIKey: WHTVZRBIWZFKQO-UHFFFAOYSA-N  

 

InChI: InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21)

 

Attribute
[Chem Name]	4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine
[Synonym]	Chloroquine; NSC-187208; CHQ; CQ
[CAS No.]	54-05-7
[EINECS]	200-191-2
[MDL No.]	MFCD00024009
[Formula]	C18H26ClN3
[Molecular]	319.87
[Form]	White to Light Brown
[Storage]	Keep in dark place. Sealed in dry, 2-8°C

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