WEHI-539 had high affinity (IC50=1.1 nM) and selectivity for BCL-XL, and it could kill cells effectively. Its affinity for Bcl-XL is 400-fold greater than that for other BCL-2 family members.

 

Brand: BCM

 

Target: BCL

 

Signaling Pathways: Apoptosis

 

In Vitro: WEHI-539 induces noticeable PARP cleavage in Ovcar-4 (5 μM in Ovcar-4.) and Ovsaho (1 μM in Ovsaho) cells. WEHI-539 augments Carboplatin induced caspase 3/7 activity, PARP cleavage, and annexin V labeling.

 

Boiling Point: 827.6±75.0 °C(Predicted)

 

pKa: 10.24±0.20(Predicted)

 

Solubility: Insoluble in DMSO; Insoluble in Water.

 

Isomeric SMILES: C1CC2=C(C=C(C=C2)C3=NC(=C(S3)CCCOC4=CC=C(C=C4)CN)C(=O)O)/C(=N/NC5=NC6=CC=CC=C6S5)/C1  

 

InChIKey: JKMWZKPAXZBYEH-JWHWKPFMSA-N  

 

InChI: InChI=1S/C31H29N5O3S2/c32-18-19-10-14-22(15-11-19)39-16-4-9-27-28(30(37)38)34-29(40-27)21-13-12-20-5-3-7-24(23(20)17-21)35-36-31-33-25-6-1-2-8-26(25)41-31/h1-2,6,8,10-15,17H,3-5,7,9,16,18,32H2,(H,33,36)(H,37,38)/b35-24+

 

Attribute
[Chem Name]	5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid
[Synonym]	WEHI-539
[CAS No.]	1431866-33-9
[MDL No.]	MFCD25372044
[Formula]	C31H29N5O3S2
[Molecular]	583.72
[Form]	Solid Powder
[Storage]	Store at -20°C

Goods Tag