BAI1 is a direct allosteric inhibitor of BAX with a Kd value of 15.0 ± 4 μM.

 

Brand: BCM

 

Target: Apoptosis; BCL

Signaling Pathways: Apoptosis

 

In Vitro: V-9302 inhibited ASCT2-mediated glutamine uptake in human cells in a concentration-dependent fashion and exhibited a 100-fold improvement in potency (IC50 V-9302 = 9.6 μM) over gamma-L-glutamyl-p-nitroanilide (GPNA; IC50 = 1000 μM). The EC50 concentration

 

Boiling Point: 388.1±42.0 °C(Predicted)

 

pKa: 14.48±0.20(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: C1CN(CCN1)CC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)O.Cl.Cl  

 

InChIKey: HWFKCAFKXZFOQT-UHFFFAOYSA-N  

 

InChI: InChI=1S/C19H21Br2N3O.2ClH/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)24(18)12-15(25)11-23-7-5-22-6-8-23;;/h1-4,9-10,15,22,25H,5-8,11-12H2;2*1H

 

Attribute
[Chem Name]	1-(3,6-dibromocarbazol-9-yl)-3-piperazin-1-ylpropan-2-ol;dihydrochloride
[Synonym]	BAI1
[CAS No.]	335165-68-9
[MDL No.]	MFCD00276492
[Formula]	C19H21Br2N3O
[Molecular]	467.2
[Form]	White solid
[Storage]	Keep in dark place. Inert atmosphere. Room temperature

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