MLN120B (ML120B) is a potent, selective, reversible, and ATP-competitive IkappaB kinase β (IKKβ) inhibitor with an IC50 of 45 nM against recombinant IKKβ. MLN120B did not inhibit other IKK isoforms at IC50 below 50 μM.

 

Brand: BCM

 

Target: IκB/IKK

 

Signaling Pathways: NF-κB

 

In Vitro: MLN120B almost completely blocks the stimulation of MM.1S, U266, and INA6 cell growth, as well as IL-6 secretion from BMSCs, induced by multiple myeloma cell adherence to BMSCs. MLN120B shows an inhibitory effect on LPS induced NF-κB activation in RAW267.4 cells. The IC50 values of MLN120B is 1.4, 14.8 or 27.3 μM for NF-κB2-luc2, IL8-luc2 or TNF-AIP3-luc2 reporter transfected cells, respectively.

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC1=C(C=CC=N1)C(=O)NC2=C3C(=CC(=C2OC)Cl)C4=C(N3)C=NC=C4  

 

InChIKey: ZNOLRTPMNMPLHY-UHFFFAOYSA-N  

 

InChI: InChI=1S/C19H15ClN4O2/c1-10-11(4-3-6-22-10)19(25)24-17-16-13(8-14(20)18(17)26-2)12-5-7-21-9-15(12)23-16/h3-9,23H,1-2H3,(H,24,25)

 

Attribute
[Chem Name]	N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylpyridine-3-carboxamide
[Synonym]	MLN120B; ML120B
[CAS No.]	783348-36-7
[MDL No.]	MFCD17392835
[Formula]	C19H15ClN4O2
[Molecular]	366.8
[Form]	Solid Powder
[Storage]	Keep in dark place. Inert atmosphere. Room temperature

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