Homoplantaginin (Hispidulin-7-glucoside) is the major flavonoid in the Chinese herbal medicine Salvia miltiorrhiza, which has anti-inflammatory and antioxidant effects. Homoplantaginin inhibited TNF-α and IL-6 mRNA expression and phosphorylation of IKKβ and NF-κB.

 

Brand: BCM

 

Target: TNF; NF-κB

 

Signaling Pathways: Apoptosis; NF-κB

 

In Vitro: Homoplantaginin may be used for the prevention and treatment of endothelial dysfunction associated with insulin resistance, it ameliorates endothelial insulin resistance by inhibiting inflammation and modulating cell signalling via the IKKβ/IRS-1/pAkt/peNOS pathway.

 

Melting Point: 256-258℃

 

Boiling Point: 798.1±60.0 °C(Predicted)

 

pKa: 6.11±0.40(Predicted)

 

Solubility: Soluble in DMSO.

 

GHS: GHS07

Isomeric SMILES: COC1=C(C=C2C(=C1O)C(=O)C=C(O2)C3=CC=C(C=C3)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O  

 

InChIKey: GCLAFEGUXXHIFT-IWLDQSELSA-N  

 

InChI: InChI=1S/C22H22O11/c1-30-21-14(32-22-20(29)19(28)17(26)15(8-23)33-22)7-13-16(18(21)27)11(25)6-12(31-13)9-2-4-10(24)5-3-9/h2-7,15,17,19-20,22-24,26-29H,8H2,1H3/t15-,17-,19+,20-,22-/m1/s1

 

Attribute
[Chem Name]	5-hydroxy-2-(4-hydroxyphenyl)-6-methoxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
[Synonym]	Homoplantaginin; Hispidulin-7-glucoside
[CAS No.]	17680-84-1
[MDL No.]	MFCD04039835
[Formula]	C22H22O11
[Molecular]	462.41
[Form]	A solid
[Storage]	Store at -20°C

Goods Tag