PDTC (Pyrrolidinedithiocarbamate ammonium) is an effective inhibitor of the nf-kappa B, inhibitory kappa B phosphorylation predominate, I stop the nf-kappa B translocation into nuclear and reduce downstream the expression of cytokines.

 

Brand: BCM

 

Target: NF-κB

 

Signaling Pathways: NF-κB

 

In Vitro: Pretreatment of cells with PDTC (3-1000 mM) dose-dependently attenuate IL-8 production. Furthermore, PDTC (100 mM) suppresses the accumulation of IL-8 mRNA. PDTC inhibites the activation of NF-kB, because PDTC suppresses both NF-kB DNA binding and NF-kB-dependent transcriptional activity. Taken together, our data demonstrate that NF-kB inhibition with PDTC decrease IL-8 production by intestinal epithelial cells.

 

Melting Point: 153-155 °C(lit.)

 

PH: 6-7 (50g/l, H2O, 20℃)

 

Solubility: Soluble in Water; Soluble in DMSO; Soluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C1CCN(C1)C(=S)[S-].[NH4+]  

 

InChIKey: MDDIUTVUBYEEEM-UHFFFAOYSA-N  

 

InChI: InChI=1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3

 

Attribute
[Chem Name]	azanium;pyrrolidine-1-carbodithioate
[Synonym]	PDTC; Pyrrolidinedithiocarbamate ammonium; APDC; Pyrrolidine dithiocarbamic acid ammonium salt
[CAS No.]	5108-96-3
[EINECS]	225-834-4
[MDL No.]	MFCD00012720
[Formula]	C5H9NS2.H3N
[Molecular]	164.3
[Form]	White to off-white solid powder
[Storage]	Inert atmosphere. Room Temperature

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