JNJ0966 is a highly selective compound that inhibits the activation of MMP-9 zymogen and the subsequent generation of catalytically active enzymes. JNJ0966 had no effect on the catalytic activity of MMP-1, MMP-2, MMP-3, MMP-9 or MMP-14 and did not inhibit the activation of MMP-2 proenzyme.

 

Brand: BCM

 

Target: MMP

 

Signaling Pathways: Proteases/Proteasome

 

In Vitro: The activations of proMMP-1, proMMP-2, and proMMP-3 are not significantly different in the presence or absence of 10 μM JNJ0966, whereas proMMP-9 activation by trypsin is significantly attenuated by JNJ0966. The addition of JNJ0966 to the reaction results in a significant reduction in fully processed MMP-9 and an apparent accumulation of the intermediate species.

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

Isomeric SMILES: CC1=C(SC(=N1)NC(=O)C)C2=CSC(=N2)NC3=CC=CC=C3OC  

 

InChIKey: ZADCDCMLLGDCRM-UHFFFAOYSA-N  

 

InChI: InChI=1S/C16H16N4O2S2/c1-9-14(24-16(17-9)18-10(2)21)12-8-23-15(20-12)19-11-6-4-5-7-13(11)22-3/h4-8H,1-3H3,(H,19,20)(H,17,18,21)

 

Attribute
[Chem Name]	N-[5-[2-(2-methoxyanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]acetamide
[Synonym]	JNJ0966
[CAS No.]	315705-75-0
[MDL No.]	MFCD02045222
[Formula]	C16H16N4O2S2
[Molecular]	360.45
[Form]	A crystalline solid
[Storage]	Inert atmosphere. Room Temperature

Goods Tag