Rilematovir (JNJ-678, JNJ-53718678) is an antiviral agent that inhibits respiratory syncytial virus (RSV) with an EC50 of 1.2 nM in HBEC. Rilematovir is also a fusion protein inhibitor.

 

Brand: BCM

 

Target: EGFR; RSV

 

Signaling Pathways: Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors

 

In Vitro: Rilematovir is highly active against a number of RSV strains from both A and B subtypes, especially the A2 strain. The EC50 of HeLa cells is 460 pM.

 

In Vivo: Rilematovir efficiently suppresses established acute lower respiratory tract infection in the animals after oral treatment of neonatal lambs with Rilematovir, or with an equally active close analog.

 

Boiling Point: 672.5±55.0 °C(Predicted)

 

pKa: 6.39±0.20(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CS(=O)(=O)CCCN1C2=C(C=C(C=C2)Cl)C=C1CN3C4=C(C=CN=C4)N(C3=O)CC(F)(F)F  

 

InChIKey: GTQTUABHRCWVLL-UHFFFAOYSA-N  

 

InChI: InChI=1S/C21H20ClF3N4O3S/c1-33(31,32)8-2-7-27-16(10-14-9-15(22)3-4-17(14)27)12-28-19-11-26-6-5-18(19)29(20(28)30)13-21(23,24)25/h3-6,9-11H,2,7-8,12-13H2,1H3

 

Attribute
[Chem Name]	3-[[5-chloro-1-(3-methylsulfonylpropyl)indol-2-yl]methyl]-1-(2,2,2-trifluoroethyl)imidazo[4,5-c]pyridin-2-one
[Synonym]	JNJ-678; Rilematovir; JNJ-53718678
[CAS No.]	1383450-81-4
[MDL No.]	MFCD30489307
[Formula]	C21H20ClF3N4O3S
[Molecular]	500.92
[Form]	A crystalline solid
[Storage]	Store at -20°C

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