KDU691 is a specific inhibitor of Plasmodium PI4K, with IC50 values of 0.18 μM and 0.061 μM against the resting daughter form and the hepatic schizont, respectively.

 

Brand: BCM

 

Target: Parasite; PI4K

 

Signaling Pathways: Microbiology/Virology; PI3K/Akt/mTOR signaling

 

In Vivo: KDU691 was evaluated for in vivo activity in rhesus macaques infected with P. cynomolgi sporozoites.?The prophylactically treated monkeys failed to become blood smear positive, while untreated control animals showed normal parasitemia development (primary parasitemia at day 8.9 p.i., with the first relapse within a month).?Thus, 5-day oral treatment with 20 mg/kg of KDU691 shortly after infection eradicated all liver-stage parasites, including hypnozoites.

 

pKa: 14.59±0.46(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CNC(=O)C1=CC=C(C=C1)C2=CN=C3N2C=C(N=C3)C(=O)N(C)C4=CC=C(C=C4)Cl  

 

InChIKey: TYMFFISSODJRDV-UHFFFAOYSA-N  

 

InChI: InChI=1S/C22H18ClN5O2/c1-24-21(29)15-5-3-14(4-6-15)19-11-26-20-12-25-18(13-28(19)20)22(30)27(2)17-9-7-16(23)8-10-17/h3-13H,1-2H3,(H,24,29)

 

Attribute
[Chem Name]	N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide
[Synonym]	KDU691
[CAS No.]	1513879-19-0
[MDL No.]	MFCD28963927
[Formula]	C22H18ClN5O2
[Molecular]	419.86
[Form]	Solid Powder
[Storage]	Keep in dark place. Inert atmosphere. Room temperature

Goods Tag