BQR695 (NVP-BQR695) is a PI4KIIIβ inhibitor with an IC50 of approximately 90 nM against human PI4KIIIβ.

 

Brand: BCM

 

Target: PI3K; Parasite; PI4K

 

Signaling Pathways: Microbiology/Virology; PI3K/Akt/mTOR signaling

 

In Vitro: BQR695 shows no evidence of toxicity against mature red blood cells (RBCs), induces a schizont-stage arrest indistinguishable from that observed in imidazopyrazine-treated parasites and exhibits cross-resistance with the imidazopyrazine-resistant lines. Treatment with 0.5 μM of either KAI407 or BQR695 causes GFP-PHOsh2 to redistribute to the parasite plasma membrane, consistent with depletion of intracellular PI4P upon inhibition of PfPI4K function.

 

Boiling Point: 607.1±55.0 °C(Predicted)

 

pKa: 15.14±0.46(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: CNC(=O)CNC1=CN=C2C=CC(=CC2=N1)C3=CC(=C(C=C3)OC)OC  

 

InChIKey: LYPCULYCGFOIDA-UHFFFAOYSA-N  

 

InChI: InChI=1S/C19H20N4O3/c1-20-19(24)11-22-18-10-21-14-6-4-12(8-15(14)23-18)13-5-7-16(25-2)17(9-13)26-3/h4-10H,11H2,1-3H3,(H,20,24)(H,22,23)

 

Attribute
[Chem Name]	2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide
[Synonym]	BQR695; NVP-BQR695
[CAS No.]	1513879-21-4
[MDL No.]	MFCD30533463
[Formula]	C19H20N4O3
[Molecular]	352.39
[Form]	Solid Powder
[Storage]	Keep in dark place. Sealed in dry, 2-8°C

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