ML359 is a small molecule inhibitor of protein disulfide isomerase (PDI).

 

Brand: BCM

 

In Vitro: ML359 shown to be a specific inhibitor of PDI.?ML359 shows no cytotoxicity in three human cell lines, and some activity in inhibiting platelet aggregation in vitro.?ML359 will provide more understanding of the mechanisms of PDI in platelet functions.?It also could lead to the development of a new class of antithrombotics that could establish PDI as suitable drug target.

 

Boiling Point: 517.3±50.0 °C(Predicted)

 

pKa: 8.42±0.20(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CCN(C1=NN(C2=C1C=C3C=CC(=CC3=N2)OC)C)C(=O)C4=CC=CO4  

 

InChIKey: GKJQVQCIPPIODP-UHFFFAOYSA-N  

 

InChI: InChI=1S/C19H18N4O3/c1-4-23(19(24)16-6-5-9-26-16)18-14-10-12-7-8-13(25-3)11-15(12)20-17(14)22(2)21-18/h5-11H,4H2,1-3H3

 

Attribute
[Chem Name]	N-ethyl-N-(7-methoxy-1-methylpyrazolo[3,4-b]quinolin-3-yl)furan-2-carboxamide
[CAS No.]	1069858-99-6
[MDL No.]	MFCD32669808
[Formula]	C23H28ClNO4
[Molecular]	417.93
[Form]	Solid powder
[Storage]	Stored at -20°C

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