SEA0400 is a potent inhibitor of a selective Na+-Ca2+ exchanger (NCX) that inhibits Na+ -dependent Ca2+ uptake in neurons, astrocytes, and microglia with IC50 values of 33 nM, 5.0 nM, and 8.3 nM, respectively. SEA0400 prevents sodium nitroside (SNP) from enhancing ERK and p38 MAPK phosphorylation and reactive oxygen species (ROS) production in an extracellular Ca2+ -dependent manner.

 

Brand: BCM

 

Target: Calcium Channel; Na+/Ca2+ Exchanger

 

Signaling Pathways: Membrane transporter/Ion channel; Metabolism

 

In Vitro: SEA0400 inhibits Na+-dependent 45Ca2+ uptake in cultured neurons, astrocytes, and microglia. IC50 values of SEA0400 are 33 nM (neurons), 5.0 nM (astrocytes), and 8.3 nM (microglia). SEA0400 prevents sodium nitroprusside (SNP) to increase ERK and p38 MAPK phosphorylation, and production of reactive oxygen species (ROS) in an extracellular Ca2+-dependent manner.

 

Boiling Point: 485.0±45.0 °C(Predicted)

 

pKa: 4.04±0.10(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CCOC1=CC(=C(C=C1)OC2=CC=C(C=C2)OCC3=C(C=CC(=C3)F)F)N  

 

InChIKey: YSUBLPUJDOWYDP-UHFFFAOYSA-N  

 

InChI: InChI=1S/C21H19F2NO3/c1-2-25-18-8-10-21(20(24)12-18)27-17-6-4-16(5-7-17)26-13-14-11-15(22)3-9-19(14)23/h3-12H,2,13,24H2,1H3

 

Attribute
[Chem Name]	2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline
[Synonym]	SEA0400; SEA-0400
[CAS No.]	223104-29-8
[MDL No.]	MFCD07772188
[Formula]	C21H19F2NO3
[Molecular]	371.38
[Form]	Solid powder
[Storage]	Keep in dark place. Inert atmosphere. Store in freezer, under -20°C

Goods Tag