Danshensu (Salvianic acid A), a Chinese herbal medicine in traditional Chinese medicine, has potential anti-tumor and anti-angiogenic effects. Danshensu inhibited CYP2E1 and CYP2C9 with IC50 values of 36.63 μm and 75.76 μm, respectively.

 

Brand: BCM

 

Target: Apoptosis; Nrf2; Autophagy

 

Signaling Pathways: Apoptosis; Autophagy; Immunology/Inflammation

 

In Vitro: Danshensu reduces lipid peroxidation on mitochondrial membrane by scavenging free radicals, and inhibits permeability and transmission of mitochondrial membrane by reducing thiol oxidation. Danshensu markedly improves cell viability and decreased lactate dehydrogenase (LDH) release in H9c2 cardiomyocytes. Danshensu increases phosphorylation of Akt and extracellular signal-related kinase 1/2 (ERK1/2) in H9c2 cells, and the protective effects of Danshensu are partially inhibited by phosphatidylinositol 3'-kinase (PI3K) specific inhibitor wortmannin or ERK specific inhibitor U0126. Danshensu could provide significant cardioprotection against MI/R injury, and the potential mechanisms might to suppression of cardiomyocytes apoptosis through activating the PI3K/Akt and ERK1/2 signaling pathways. Danshensu increases Bcl-2 expression and decreases Bax, active caspase-3 expression by activating Akt and ERK signaling pathways. Danshensu has been demonstrated to have biological activities in improving microcirculation, suppressing the formation of reactive oxygen species, inhibiting platelet adhesion and aggregation, protecting myocardium against ischemia, protecting endothelial cells against injury induced by inflammation.

 

Melting Point: >210°C (dec.)

 

Boiling Point: 481.5±40.0 °C(Predicted)

 

pKa: 3.82±0.10(Predicted)

 

Solubility: Soluble in Water. Insoluble in DMSO; Insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C1=CC(=C(C=C1C[C@H](C(=O)O)O)O)O  

 

InChIKey: PAFLSMZLRSPALU-MRVPVSSYSA-N  

 

InChI: InChI=1S/C9H10O5/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14/h1-3,8,10-12H,4H2,(H,13,14)/t8-/m1/s1

 

Attribute
[Chem Name]	(2R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid
[Synonym]	Danshensu; Salvianic acid A
[CAS No.]	76822-21-4
[MDL No.]	MFCD09750417
[Formula]	C9H10O5
[Molecular]	198.17
[Form]	Light Beige Solid
[Storage]	Inert atmosphere. Room Temperature

Goods Tag