APD-597 (JNJ-38431055) is a potent and selective G protein-coupled receptor 119 (GPR119) agonist with an EC50 value of 46 nM for hGPR119. It is also an inhibitor of Cytochrome P450 2C9 (CYP2C9) with an IC50 value of 5.8 μM. APD-597 (JNJ-38431055) was developed for the treatment of type 2 diabetes mellitus (T2D).

 

Brand: BCM

 

Target: GPR

 

Signaling Pathways: Endocrinology/Hormones; GPCR/G Protein

 

Boiling Point: 648.3±55.0 °C(Predicted)

 

pKa: 2.43±0.10(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

Isomeric SMILES: CC1=C(C=CC(=N1)S(=O)(=O)C)NC2=C(C(=NC=N2)OC3CCN(CC3)C(=O)OC(C)C)OC  

 

InChIKey: WPDCHTSXOPUOII-UHFFFAOYSA-N  

 

InChI: InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25) 

 

Attribute
[Chem Name]	propan-2-yl 4-[5-methoxy-6-[(2-methyl-6-methylsulfonylpyridin-3-yl)amino]pyrimidin-4-yl]oxypiperidine-1-carboxylate
[CAS No.]	897732-93-3
[MDL No.]	MFCD25976734
[Formula]	C21H29N5O6S
[Molecular]	479.55
[Form]	A crystalline solid
[Storage]	Keep in dark place. Inert atmosphere, 2-8°C
[Synonym]	APD597; JNJ-38431055; APD-597

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