SRX3207 is an orally active dual inhibitor of Syk-PI3K, The IC50 values of Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta and PI3K gamma were 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM and 9790, respectively nM. SRX3207 blocks tumor immunosuppression and increases antitumor immunity.

 

Brand: BCM

 

Target: Others; PI3K; Syk

 

Signaling Pathways: Angiogenesis; Others; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors

 

In Vitro: The IC50 values are 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 (10 μmol/L) blocks p-AKT.

 

Solubility: Soluble In DMSO. Insoluble in Water; Insoluble in Ethanol.

 

Isomeric SMILES: CC1=NN(C=C1CN2CCC2)C3=NC(=NC=C3)NC4=CC=C(C=C4)C5=CSC6=C5OC(=CC6=O)N7CCOCC7  

 

InChIKey: ZZVOPDBZUNUMPR-UHFFFAOYSA-N  

 

InChI: InChI=1S/C29H29N7O3S/c1-19-21(16-34-9-2-10-34)17-36(33-19)25-7-8-30-29(32-25)31-22-5-3-20(4-6-22)23-18-40-28-24(37)15-26(39-27(23)28)35-11-13-38-14-12-35/h3-8,15,17-18H,2,9-14,16H2,1H3,(H,30,31,32)

 

Attribute
[Chem Name]	3-[4-[[4-[4-(azetidin-1-ylmethyl)-3-methylpyrazol-1-yl]pyrimidin-2-yl]amino]phenyl]-5-morpholin-4-ylthieno[3,2-b]pyran-7-one
[Synonym]	SRX3207
[CAS No.]	2254693-15-5
[MDL No.]	MFCD33402171
[Formula]	C29H29N7O3S
[Molecular]	555.65
[Form]	Solid Powder
[Storage]	Stored at -20°C

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