Orforglipron(LY3502970) is a nonpeptide agonist of the glucagon-like peptide 1(GLP-1) receptor. It is effective for glycemic control and weight loss in type 2 diabetes mellitus (T2DM), obesity, or both.

 

Brand: BCM

 

Target: Glucagon Receptor

 

Signaling Pathways: GPCR/G Protein

 

In Vitro: GLP-1 exhibits various actions such as dependent gastric emptying delay, and feeding suppression.GLP-1 is an incretin secreted from L cells of the small intestine when nutrients pass through the digestive tract, and glucose is transmitted via the GLP-1 receptor.

 

pKa: 7.33±0.20(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

Isomeric SMILES: C[C@H]1C[C@]1(C2=NOC(=O)N2)N3C4=C(C=C(C=C4)[C@H]5CCOC(C5)(C)C)C=C3C(=O)N6CCC7=NN(C(=C7[C@@H]6C)N8C=CN(C8=O)C9=C(C1=C(C=C9)N(N=C1)C)F)C1=CC(=C(C(=C1)C)F)C  

 

InChIKey: USUWIEBBBWHKNI-KHIFEHGGSA-N  

 

InChI: InChI=1S/C48H48F2N10O5/c1-25-18-32(19-26(2)40(25)49)60-42(58-16-15-57(46(58)63)37-11-10-36-33(41(37)50)24-51-55(36)7)39-28(4)56(14-12-34(39)53-60)43(61)38-21-31-20-29(30-13-17-64-47(5,6)23-30)8-9-35(31)59(38)48(22-27(48)3)44-52-45(62)65-54-44/h8-11,15-16,18-21,24,27-28,30H,12-14,17,22-23H2,1-7H3,(H,52,54,62)/t27-,28-,30-,48-/m0/s1

 

Attribute
[Chem Name]	3-[(1S,2S)-1-[5-[(4S)-2,2-dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one
[Synonym]	Orforglipron; LY3502970
[CAS No.]	2212020-52-3
[Formula]	C48H48F2N10O5
[Molecular]	882.97
[Form]	Solid powder
[Storage]	Sealed in dry. Store in freezer, under -20°C

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