D609 is a selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) with a Ki of 6.4 μM. It is an antioxidant protective agent with antiviral and anti-inflammatory activities and also inhibits angiogenesis by preventing basement membrane (BM) synthesis.

 

Brand: BCM

 

Target: Apoptosis; Antioxidant

 

Signaling Pathways: Apoptosis; oxidation-reduction

 

In Vitro: D609 (100 μM; 2 hours) significantly inhibits the proliferation of various cell lines. At concentrations of 50, 100, and 200 μM (2 hours), D609 activates caspase-3 at 200 μM, while at 50 and 100 μM, no detectable cleavage is observed. D609 (100 μM; 2 hours) markedly inhibits BrdU incorporation in BV-2 microglial cells, leading to G1 phase cell accumulation and a decrease in the number of cells in the S phase. D609 (100 μM; 2 hours, followed by 2 or 22 hours of cultivation without D609) increases ceramide levels, upregulates p21 expression, and results in decreased phosphorylation of Rb.

 

Solubility: Soluble in DMSO; Soluble in Water; Soluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C1CC2C(C1)C3CC2CC3OC(=S)[S-].[K+]  

 

InChIKey: IGULCCCBGBDZKQ-UHFFFAOYSA-M  

 

InChI: InChI=1S/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14);/q;+1/p-1

 

Attribute
[Chem Name]	potassium;8-tricyclo[5.2.1.02,6]decanyloxymethanedithioate
[Synonym]	D609; Tricyclodecan-9-yl-Xanthogenate
[CAS No.]	83373-60-8
[EINECS]	280-379-9
[MDL No.]	MFCD00171401
[Formula]	C11H17KOS2
[Molecular]	268.47
[Form]	Off-white solid
[Storage]	Sealed in dry. Stored at -20°C.

Goods Tag