Mito-TEMPO (MT) is a mitochondrial-targeted superoxide dismutase mimetic that protects against the early stages of acetaminophen (APAP) hepatotoxicity by inhibiting peroxynitrite formation. Mito-TEMPO treatment inhibited APAP-induced RIP3 kinase expression.

 

Brand: BCM

 

Target: Reactive Oxygen Species; Mitochondrial Metabolism

 

Signaling Pathways: Immunology/Inflammation; Metabolism; NF-κB

 

In Vivo: Mito-Tempo could induce secondary apoptosis in the late phase of APAP hepatotoxicity. Mito-Tempo induces secondary apoptosis after APAP overdose by inhibition of RIP3.

 

Solubility: Soluble in DMSO; Soluble in Water; Soluble in Ethanol.

 

Isomeric SMILES: CC1(CC(CC(N1O)(C)C)NC(=O)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C.[Cl-]  

 

InChIKey: QJEOOHMMSUBNGG-UHFFFAOYSA-N  

 

InChI: InChI=1S/C29H35N2O2P.ClH/c1-28(2)20-23(21-29(3,4)31(28)33)30-27(32)22-34(24-14-8-5-9-15-24,25-16-10-6-11-17-25)26-18-12-7-13-19-26;/h5-19,23,33H,20-22H2,1-4H3;1H.

 

Attribute
[Chem Name]	[2-[(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)amino]-2-oxoethyl]-triphenylphosphanium;chloride
[Synonym]	Mito-TEMPO
[CAS No.]	1334850-99-5
[MDL No.]	MFCD26406410
[Formula]	C29H35ClN2O2P
[Molecular]	510.03
[Form]	White to light brown powder
[Storage]	Keep in dark place. Inert atmosphere. Store in freezer, under -20°C

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