OD36 is an inhibitor of RIPK2 with an IC50 value of 5.3 nM. OD36 is a macrocyclic inhibitor that binds efficiently to the ALK2 kinase ATP pocket.

 

Brand: BCM

 

Target: ALK; RIP kinase

 

Signaling Pathways: Angiogenesis; Apoptosis; NF-κB; Tyrosine Kinase/Adaptors

 

In Vitro: OD36 shows activity against ALK1 (KD=90 nM). OD36 potently antagonizes mutant ALK2 signaling and osteogenic differentiation. OD36 (0.1-1 μM; 24 h; KS483 cells) efficiently inhibits BMP-6 (50 ng/mL)-induced p-Smad1/5. OD36 (0.5 μM) completely prevents the activation of Smad1/5 and the gene targets ID-1 and ID-3 in response to activin A in preincubated fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs).

 

Boiling Point: 501.7±50.0 °C(Predicted)

 

pKa: 4.79±0.20(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

Isomeric SMILES: C1COCCOC2=CC(=CC(=C2)C3=C4N=C(N1)C=CN4N=C3)Cl  

 

InChIKey: KTSDBMVHAKWDRK-UHFFFAOYSA-N  

 

InChI: InChI=1S/C16H15ClN4O2/c17-12-7-11-8-13(9-12)23-6-5-22-4-2-18-15-1-3-21-16(20-15)14(11)10-19-21/h1,3,7-10H,2,4-6H2,(H,18,20) 

 

Attribute
[Chem Name]	4-chloro-7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene
[Synonym]	OD36
[CAS No.]	1638644-62-8
[Formula]	C16H15ClN4O2
[Molecular]	330.77
[Form]	Solid Powder
[Storage]	Sealed in dry. Stored at -20°C.

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