AZD3463 is a novel, orally potent ALK inhibitor with a Ki of 0.75 nM that also equivalently inhibits IGF1R. AZD3463 can inhibit cell viability by inducing apoptosis and autophagy.

 

Brand: BCM

 

Target: Apoptosis; IGF-1R; ALK; Autophagy

 

Signaling Pathways: Angiogenesis; Apoptosis; Autophagy; Tyrosine Kinase/Adaptors

 

In Vitro: AZD-3463 was equally effective against mutant L1196M and wild-type ALK in vivo. When acting on transplanted tumors in vivo,AZD-3463 inhibited pALK in a dose-dependent manner, resulting in tumor volume arrest (H3122) or decline (DEL,H2228).

 

Boiling Point: 723.6±70.0 °C(Predicted)

 

pKa: 14.62±0.30(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

Isomeric SMILES: COC1=C(C=CC(=C1)N2CCC(CC2)N)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl  

 

InChIKey: GCYIGMXOIWJGBU-UHFFFAOYSA-N  

 

InChI: InChI=1S/C24H25ClN6O/c1-32-22-12-16(31-10-8-15(26)9-11-31)6-7-21(22)29-24-28-14-19(25)23(30-24)18-13-27-20-5-3-2-4-17(18)20/h2-7,12-15,27H,8-11,26H2,1H3,(H,28,29,30)

 

Attribute
[Chem Name]	N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine
[Synonym]	AZD3463
[CAS No.]	1356962-20-3
[MDL No.]	MFCD25976759
[Formula]	C24H25ClN6O
[Molecular]	448.95
[Form]	Solid
[Storage]	Keep in dark place. Sealed in dry. Store in freezer, under -20°C

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