Ac-FLTD-CMK is a specific inhibitor of inflammatory caspases. Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage through caspases-1, -4, -5, and -11 in vitro. The IC50 values of caspases-1, caspases-4 and caspases-5 by Ac-FLTD-CMK were 46.7 nM, 1.49 μM and 329 nM, respectively.

 

Brand: BCM

 

Target: Caspase

 

Signaling Pathways: Apoptosis; Proteases/Proteasome

 

In Vitro: Ac-FLTD-CMK, inhibits GSDMD cleavage by caspases-1, -4, -5, and -11 in vitro, suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages. By contrast, Ac-FLTD-CMK does not target caspase-3 or apoptotic cell death. Crystal structure of caspase-1 in complex with Ac-FLTD-CMK reveals extensive enzyme-inhibitor interactions involving both hydrogen bonds and hydrophobic contacts.

 

Boiling Point: 962.7±65.0 °C(Predicted)

 

pKa: 3.93±0.19(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: C[C@H]([C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)CCl)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C)O  

 

InChIKey: UCWNTWGHVCSMJP-WPUDHWPRSA-N  

 

InChI: InChI=1S/C26H37ClN4O8/c1-14(2)10-19(30-24(37)20(28-16(4)33)11-17-8-6-5-7-9-17)25(38)31-23(15(3)32)26(39)29-18(12-22(35)36)21(34)13-27/h5-9,14-15,18-20,23,32H,10-13H2,1-4H3,(H,28,33)(H,29,39)(H,30,37)(H,31,38)(H,35,36)/t15-,18+,19+,20+,23+/m1/s1

 

Attribute
[Chem Name]	(3S)-3-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-acetamido-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-5-chloro-4-oxopentanoic acid
[Synonym]	Ac-FLTD-CMK
[CAS No.]	2376255-48-8
[MDL No.]	MFCD32874101
[Formula]	C26H37ClN4O8
[Molecular]	569.05
[Form]	Solid powder
[Storage]	Store at -20°C, protect from light, stored under nitrogen

Goods Tag