TAK-659 is a potent and selective SYK inhibitor. IC50 is 3.2 nM. It is selective to other kinases and can effectively inhibit FLT3 with IC50 of 4.6 nM.

 

Brand: BCM

 

Solubility: Soluble in DMSO and Water.

 

InChi Key: BZSLKYUVNSVQRA-UVDYRLMLSA-N

 

Attribute
[CAS No.]	1952251-28-3
[Chem Name]	TAK-659
[Synonym]	6-(((1R,2S)-2-Aminocyclohexyl)amino]-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridin-3(2H)-one dihydrochloride; TAK 659; 3H-Pyrrolo[3,4-c]pyridin-3-one, 6-[[(1R,2S)-2-aminocyclohexyl]amino]-7-fluoro-1,2-dihydro-4-(1-methyl-1H-pyrazol-4-yl)-, hydrochloride (1:1);
[Formula]	C17H22ClFN6O
[Molecular]	380.84800
[MDL No.]	MFCD31544322
[Form]	White to off-white solid powder

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