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Venetoclax (ABT-199, GDC-0199) is a selective inhibitor of Bcl-2 with a Ki of <0.01 nM in cell-free tests, which is more than 4800 times more selective than that used for Bcl-xL and Bcl-w, and has no inhibitory activity against Mcl-1. Phase 3.
Brand: BCM
Melting Point: >150°C (dec.)
pKa: 4.09±0.10(Predicted)
Solubility: Soluble in DMSO. Insoluble in Water.
Attribute [Chem Name] GDC-0199 [Synonym] ABT 199;GDC0199;GDC 0199;Venetoclax ; abt 199;4-(4-((2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl)methyl)-1-piperazinyl)-n-((3-nitro-4-(((tetrahydro-2h-pyran-4-yl)methyl [CAS No.] 1257044-40-8 [EINECS] 820-130-9 [Formula] C45H50ClN7O7S [Molecular] 868.4392 [Form] Light Yellow to Yellow Solid [Storage] -20°C [MDL No.] MFCD23160052
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